• Angiotensin III: The Essential Peptide for RAAS and Cardi...

  2025-10-21

  Angiotensin III (human, mouse) is a versatile tool for deciphering renin-angiotensin-aldosterone system (RAAS) signaling and modeling cardiovascular or neuroendocrine disorders. This article unpacks advanced experimental workflows, troubleshooting strategies, and emerging applications—including COVID-19 pathogenesis—where Angiotensin III outperforms conventional RAAS reagents.

• Cisapride (R 51619): Mechanistic Insights and Strategic I...

  2025-10-20

  This thought-leadership article unpacks how Cisapride (R 51619)—a nonselective 5-HT4 receptor agonist and potent hERG potassium channel inhibitor—enables next-generation cardiac electrophysiology research and predictive cardiotoxicity modeling. By blending mechanistic depth with strategic guidance, we address the evolving needs of translational researchers and highlight the integration of iPSC-derived models and deep learning approaches for de-risking drug discovery. Anchored in evidence from recent high-content phenotypic screens, the piece articulates best practices, competitive context, and a visionary outlook, while contextually promoting Cisapride’s unique value proposition.

• DIDS: Precision Chloride Channel Blockade for Cancer and ...

  2025-10-19

  DIDS (4,4'-Diisothiocyanostilbene-2,2'-disulfonic Acid) stands out as a benchmark anion transport inhibitor, enabling transformative advances in cancer metastasis modeling, neurodegeneration studies, and vascular research. This article delivers stepwise experimental guidance, advanced applications, and troubleshooting strategies to maximize the translational impact of DIDS across diverse research settings.

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